A medical doctor that specializes in pathology is called a pathologist. We have entered an era of evidence based medicine.Both treating doctor and patients are hesitant to start the treatment without evidence of the disease.Pathology provides the much needed evidence to confirm/ substantiate or exclude the diagnosis. With advent of HbA1C, Genexpert ,Hormone assays,Cancer markers,FNAC and Immunofluorescent microscopy scenario has drastically changed in disease like Diabetes,Tuberculosis,Thyroid,cancer of prostate,cancer of breast and autoimmune diseases respectively as the survival rate has vastly improved.Pathology not only help in diagnosis and treatment but also in prevention and intervention of diseases.